[Obesity and hypertriglyceridemia: high risks for disease severity and mortality in COVID-19 patients]

As COVID-19 pandemic approaching its third year, more data have shown that obesity and hypertriglyceridemia are the high-risk factors for the major complications such as acute respiratory distress syndrome, thromboembolism, coagulopathy and cytokine storm, which are responsible for the majority of disease severity and mortality. In this review article, we have analyzed the public available clinical reports and laboratory research results of the COVID-19 studies by researchers and clinicians of many nations around the world. Many of these reports covered COVID-19 patients of different ethnic groups. We suggested that obesity and high triglycerides are high risks for severe COVID-19 and death. We also summarized the possible underlying molecular mechanism likely connecting the severe COVID-19 with obesity and hypertriglyceridemia. From public health perspective, we highlight the importance of the healthy diet and lifestyle in fighting against SARS-CoV-2 virus in long period of time.

Exploring individuals' effective preventive measures against epidemics through reinforcement learning

Individuals' preventive measures, as an effective way to suppress epidemic transmission and to protect themselves from infection, have attracted much academic concern, especially during the COVID-19 pandemic. In this paper, a reinforcement learning-based model is proposed to explore individuals' effective preventive measures against epidemics. Through extensive simulations, we find that the cost of preventive measures influences the epidemic transmission process significantly. The infection scale increases as the cost of preventive measures grows, which means that the government needs to provide preventive measures with low cost to suppress the epidemic transmission. In addition, the effective preventive measures vary from individual to individual according to the social contacts. Individuals who contact with others frequently in daily life are highly recommended to take strict preventive measures to protect themselves from infection, while those who have little social contacts do not need to take any measures considering the inevitable cost. Our research contributes to exploring the effective measures for individuals, which can provide the government and individuals useful suggestions in response to epidemics. © 2021 Chinese Physical Society and IOP Publishing Ltd